Cellular Interactions by Environmental Tumor Promoters: Proceedings of the 14th International Symposium of the Princess Takamatsu Cancer Research Fund, Tokyo, 1983Hirota Fujiki VSP, 1984 - 402 pages Considerable progress in our understanding of tumor promotion has been made by cancer researchers throughout the world. In addition, scientists in several other disciplines have made significant contributions in elucidating the pleiotropic effects of tumor promotion. This international symposium was specifically convened to review research progress in these areas and to consider the relevance of these findings to human cancer causation and prevention. The proceedings include the contributions of leading researchers from Europe, Japan and the USA. Several papers report the exciting progress made in understanding how tumor promoters act at the cellular and biochemical levels. Elsewhere attention is focused on tumor promotion as an important phase in the occurrence of certain human tumors. It is hoped that advances in the understanding of the mechanism of tumor promotion in experimental systems will lead to new and effective approaches to human cancer prevention. The proceedings will be of interest and value to researchers working in cancer research, biochemistry, molecular genetics, mutagenesis and cell biology. |
Table des matières
Teleocidin Aplysiatoxin and Palytoxin | 37 |
Structureactivity Studies of Aplysiatoxintype Tumor Promoters R E Moore | 49 |
Molecular Mechanisms of Tumor Promotion and Multistage Carcinogenesis | 59 |
Phorbol Ester Receptorsinsights into the Initial Events in the Mechanism | 75 |
Similarity and Dissimilarity between Phorbol Ester Tumor Promoters and la25 | 89 |
Oncogenes Inhibited Intercellular Communication and Tumor Promotion | 101 |
Expressions et termes fréquents
12-O-tetradecanoylphorbol-13-acetate 3H]PDBu 3T3 cells Acad acid adipocyte agents amplified aplysiatoxin application of TPA assay biochemical Biol biological bladder Boutwell Ca2+ Cancer Res carcinogenesis carcinogens carcinoma cell lines cellular Chem chemical compounds concentration culture debromoaplysiatoxin DHTB diacylglycerol diterpene diterpene esters DMBA DNA synthesis dose effects enhance enzyme epidermal cells Epstein-Barr virus ester tumor promoters fibroblasts Fujiki gene amplification genome growth factor Hecker human increase indole alkaloids induced inhibition inhibitor initiated cells intercellular communication irritant leukemia leukemia cells lipid liver malignant mechanism membrane mezerein mice mitogenic mouse epidermal mouse skin Natl neoplastic ng/ml nmol normal ODC activity oncogene ornithine decarboxylase palytoxin papillomas phenotype phorbol ester phorbol ester receptors phorbol ester tumor phospholipid Proc proliferation protein kinase rats response skin tumor promotion Slaga specific binding stage stimulation studies Sugimura teleocidin tigliane tion tissue transformation treatment tumor promoters virus vitro vivo weeks Weinstein